Notice of Intent to Sole Source - Custom Commercial Aptamer Procurement

The U.S. Army Combat Capabilities Development Command (DEVCOM CBC) requires a mission‑critical, ongoing supply of custom‑synthesized DNA, RNA, and peptide aptamers (including chemically modified versions) for diagnostic, biosensor, and chemical/biological defense applications. The government intends to award a firm‑fixed‑price sole‑source contract to Aptagen, LLC, the only known supplier capable of meeting the stringent quality requirements. Deliverables include lyophilized aptamers, dPAGE purification (standard HPLC is unacceptable), and double‑tier empirical quality control using ESI‑MS and 10% urea gel dPAGE for every order. Responses to the notice must be submitted via email within seven days of issuance, no later than 12:00 pm EST on 01 September 2026. • Custom synthesis, purification, QC, and delivery of DNA, RNA, and peptide aptamers • Required lyophilized form with dPAGE purification only • Mandatory empirical sequence verification (ESI‑MS + dPAGE) for each delivery • Sole‑source award to Aptagen, LLC (CAGE 436H7) • Firm‑fixed‑price contract, ongoing/continuing requirement • Submission deadline: 01 Sep 2026, email to Contract Specialist and Contracting Officer