Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development of Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)

The Blueprint Neurotherapeutics Network (BPN) invites applications to advance small molecule drug discovery and development projects for disorders of the nervous system. Participants will conduct studies involving disease- or target-specific assays, models, and other research tools in their own laboratories, collaborating with NIH-funded consultants and contract research organizations (CROs) as needed. Projects can enter at either the Discovery stage to optimize hit compounds or the Development stage to advance a development candidate through Investigational New Drug (IND)-enabling toxicology studies and phase I clinical testing. Key aspects of this opportunity include: • Advancing small molecule drug discovery and development for nervous system disorders • Collaboration with NIH-funded consultants and CROs • Projects can enter at the Discovery or Development stage • Awardee institutions retain IP rights and gain assignment of IP rights from BPN contractors • Funding is provided for all activities conducted in the applicants' own laboratories.