BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation of neural cells and circuits, to address major challenges and enable transformative understanding of dynamic signaling in the central nervous system. The proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. Some key points to consider: • The proposed technologies should be compatible with experiments in behaving animals and validated under in vivo experimental conditions. • The technologies should be capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. • Applications that seek to integrate multiple approaches are encouraged. • The proposed research should focus on demonstrating the capabilities and potential impact of the technology, rather than advancing the state of biological knowledge as the primary project goal.