Mechanistic Toxicology of METALS: Metal Exposure, Transport, Action, Localization, and Susceptibility (RP1 Clinical Trial Not Allowed)

This NIH Funding Opportunity Announcement (FOA) seeks mechanistic research on how exposure to metals and metal‑containing compounds affects human health. Applicants may propose studies that investigate metal absorption, distribution, cellular trafficking, interaction with biological systems, and mechanisms that alter immune homeostasis, cross the placental barrier, or impact the central nervous system. The FOA welcomes experimental models, novel methodological approaches, computational analyses, and the use of human biospecimens, provided that no RP1 clinical trial is involved. Up to 20 awards will be made, each ranging from $100,000 to $500,000, with total anticipated funding of $15 million. Eligible entities include a broad range of public, private, nonprofit, tribal, and academic organizations. • Focus on metal toxicology mechanisms (absorption, transport, cellular effects). • Acceptable methods: in‑vitro, animal models, computational, human biospecimen studies. • No RP1 clinical trials allowed. • Funding: $100‑$500 k per award; total $15 M across ~20 awards. • Eligibility: wide (state/local governments, universities, for‑profit, NGOs, tribal entities, etc.). • Application due 5 Jan 2027; award expected 31 Jul 2027; project start 31 Jul 2027.