One Comprehensive Universal Radiotherapy for Everyone (1-CURE) Proposers' Day

The Advanced Research Projects Agency for Health (ARPA-H) is hosting a Proposers' Day for the One Comprehensive Universal Radiotherapy for Everyone (1-CURE) program. The program aims to develop a revolutionary radiotherapy approach effective against all cancers with a single, rapid, and low-cost treatment. The 1-CURE approach involves integrating ultra-high dose rate (FLASH)-RT technology with multifunctional immunogenic smart radiotherapy biomaterials (SRBs). • The program is divided into two main technical areas: Technical Area 1 (TA1) focuses on developing immunogenic nanoparticle SRBs, and Technical Area 2 (TA2) focuses on establishing an Abscopal Treatment Planning System (ATPS) for low-cost FLASH-RT with immunogenic nanoparticle SRBs. • The Proposers' Day will include brief overview presentations, lightning talks, and private sidebar meetings between the ARPA-H team and potential proposers. • Attendees can submit one-page slides for lightning talks and teaming profiles to identify potential team members. • The program aims to accelerate healthcare outcomes for all Americans and save over $170B annually for the U.S. alone.