Description
The NIH HEAL Initiative seeks to fund a phased mechanistic clinical research program that identifies multi‑tissue mechanisms of joint pain and tests non‑pharmacologic or multimodal interventions. Up to five years of funding (Phase 1: 2‑3 years for mechanism discovery; Phase 2: 2‑3 years for intervention testing) is available through R61 (exploratory) and R33 (full) award mechanisms. Eligible applicants include universities, nonprofit research institutions, small businesses, and other U.S. entities; foreign organizations are ineligible. The program emphasizes rigorous, multimodal approaches (imaging, omics, biomechanics, digital health) and requires data‑sharing and annual progress reporting.
• Total project period ≤ 5 years (two phases of 2‑3 years each)
• Funding mechanisms: R61 (exploratory) followed by R33 (full) clinical trial support
• Focus on whole‑joint biology: muscle, adipose, ligaments, tendons, fascia, bone, cartilage, synovium, peripheral nerves
• Expected deliverables: validated mechanisms, proof‑of‑concept non‑pharmacologic interventions (e.g., physical therapy, mind‑body, biomechanical strategies)
• Eligible U.S. entities: higher‑education institutions, nonprofits, small businesses, state/local governments, tribal governments, etc.
• No cost‑sharing required; data‑management and sharing plan mandatory
• Application window: 09/28/2026 – 10/30/2026; award anticipated 07/20/2027; project start 07/27/2027.