Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research (U42 Clinical Trial Not Allowed)

The National Institutes of Health is issuing a grant notice for research models and human new approach methodologies to advance HIV/AIDS research. The grant will support two integrated priorities: the implementation of a NAMs-enabled stewardship framework and the support for high-quality SPF colony resources. The award will include core colony operations, transparent request intake and allocation, comprehensive virologic surveillance, and high-resolution immunogenetic characterization. Some key points of this opportunity include: • The grant will support the development of NAMs-enabled stewardship frameworks and SPF colony resources. • The award will include core colony operations, transparent request intake and allocation, and comprehensive virologic surveillance. • The grant will support high-resolution immunogenetic characterization to enable rigorous study design and efficient stewardship of limited in vivo resources. • The grant will support optional NAMs-enabled HIV human in vitro testing support and pilot benchmarking projects.