Viral INfections in the Young Lung- The VINYL Clinical Consortium- Data Analytics and Coordinating Center (DACC)(U24 Clinical Trial Optional)

The National Heart, Lung and Blood Institute (NHLBI) seeks to advance its mission by supporting a consortium to phenotype 0-2 year old children with severe viral lower respiratory tract infections (LRTI) with follow up until pre-school age for pulmonary sequelae. The consortium will include a Data and Analytics Coordinating Center (DACC), a Clinical Coordinating Center (CCC), a Biorepository, and four Clinical Centers (CCs). The objective of this program is to create a comprehensive understanding of the condition, predict its severity, and understand the reasons for hospitalization. Key aspects of the job include: • Phenotyping 0-2 year old children with severe viral LRTI • Follow-up until pre-school age for pulmonary sequelae • Understanding the immature host respiratory immune response to viral infection • Understanding the heterogeneity in response to different viruses • Current interventions and significant practice variation in diagnosis and management • Subsequent impact on lung health