Data Analysis and Harmonization Services for the Alzheimer’s Disease Sequencing Project (ADSP)

The National Institute on Aging (NIA), National Institutes of Health (NIH), Department of Health and Human Services (HHS), intends to negotiate and award a firm-fixed-price purchase order on a sole source basis to the Trustees of the University of Pennsylvania for Data Analysis and Harmonization Services in support of the Alzheimer’s Disease Sequencing Project (ADSP). The required services include genome analysis and harmonization on Amazon Cloud using the ADSP SNV/INDEL and SV calling pipelines, processing raw sequencing data, and providing secure cloud-based staging, storage, and dissemination consistent with ADSP and NIH controlled-access requirements. The contractor must maintain full methodological continuity with the existing ADSP harmonized dataset and provide direct comparability with the existing ADSP combined sequencing datasets. • Genome analysis and harmonization on Amazon Cloud • Processing raw sequencing data • Base quality score recalibration • Calling SNVs and indels • Calling structural variants • Quality assurance checks • Staging sequencing data on Amazon S3 standard storage • Providing storage of up to 50 GB per genome • Ensuring full methodological continuity with the existing ADSP dataset