Optimal Treatment Strategies for use of Anti-Obesity Medications (AOMs) in Children and Adolescents Clinical Centers (U01 Clinical Trial Required)

This Notice of Funding Opportunity (NOFO) invites applications from clinical centers to participate in a consortium to test anti-obesity medication (AOM) treatment strategies for youth with obesity that maximize benefits and minimize risks of AOM use. The clinical centers will collaborate on the development of protocols, use of common measures and data elements, use of a central laboratory and standardized procedures to collect data and biospecimens, and data analyses and manuscripts. The consortium will test strategies to determine optimal developmental stage for AOM initiation, rate and amount of weight loss, AOM class, dose, frequency, and duration, and content and intensity of adjunct lifestyle therapies. • The application should include a detailed plan for the recruitment and retention of participants. • The application should include a detailed plan for the collection and analysis of data. • The application should include a detailed plan for the dissemination of results. • The application should include a detailed plan for the management of the consortium. • The application should include a detailed plan for the evaluation of the consortium's progress.