Collaborative Opportunities for Multiple-disciplinary, Bold, and Integrated Endeavors (COMBINE) (RM1 Clinical Trial Optional)

The National Institute of Neurological Disorders and Stroke (NINDS) is soliciting applications from highly-integrated transdisciplinary team science to pursue a single focused goal to overcome persistent barriers, challenge orthodoxies, achieve paradigm-shifts, or develop new foundational principles in neuroscience. The research question(s) should be of sufficient scope and complexity to necessitate an innovative convergence of disciplines, expertise, and coordination, beyond the scope of traditional R01 or Program Project/Center grant mechanisms. The key aspects of this opportunity include: • The application should be led by 3-6 PDs/PIs • The team must deliver outcomes significantly advancing the NINDS mission and transform knowledge and practice within five years • The research question(s) should be of sufficient scope and complexity to necessitate an innovative convergence of disciplines, expertise, and coordination • Collaborative investigations from newly formed or established teams, combining expertise in various fields of basic, clinical, and translational domains of neuroscience will be encouraged