Multidisciplinary Research to Accelerate Hepatitis B Cure in Persons Living with HIV and HBV (MRA-HBV)

The National Institute of Allergy and Infectious Diseases (NIAID) is soliciting applications to support Multidisciplinary Research to Accelerate Hepatitis B Cure in Persons Living with HIV (PLWH) and Hepatitis B Virus (HBV). This program will focus on elucidating mechanisms of persistence and pathogenesis, discovering and developing clinically relevant biomarkers, discovering and/or validating host and/or new viral drug targets, and developing non-invasive diagnostics. Each MRA-HBV award will support an observational cohort paired with a multi-disciplinary team focused on research that leverages samples from existing clinical data and sample repositories from previous cohort studies. • The program aims to advance the understanding of Hepatitis B and HIV co-infection. • The program will support research on the mechanisms of persistence and pathogenesis of HBV. • The program will support the discovery and development of clinically relevant biomarkers and non-invasive diagnostics. • The program will support the discovery and/or validation of host and/or new viral drug targets. • The program will support research on the development of new treatments for HBV and HIV co-infection.