Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses (R21 - Clinical Trial Optional)

The National Institutes of Health (NIH) is soliciting applications for research focused on the neurological and mental health-related manifestations of infection-associated chronic illnesses, including the post-acute sequelae of COVID-19 (Neuro-PASC) and other chronic illnesses with a potential infectious trigger. The purpose of this initiative is to promote a better understanding of the neurological effects of infection-associated chronic illnesses and to accelerate the development of effective treatments. • The research should investigate the neurological and/or mental health-related mechanisms across multiple infection-associated chronic illnesses. • Applications can focus on a single condition or common mechanisms across multiple conditions. • Neurologically focused clinical research, basic experimental studies in humans, and mechanistic clinical trials are within the scope of this initiative. • Preclinical studies utilizing animal, cell culture, and/or human tissue models are also encouraged.