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U.S. Department Of Health And Human Services·District of Columbia

Agentic AI-EnableD CardioVascular CAre TransfOrmation (ADVOCATE) Innovative Solutions Opening (ISO)

Closes 4/1/2026$1M – $10MRequest for Proposal
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Description

The Advanced Research Projects Agency for Health (ARPA-H) is seeking proposals for the Agentic AI-EnableD CardioVascular CAre TransfOrmation (ADVOCATE) program, which aims to develop and implement an agentic AI system for cardiovascular disease management. The program consists of three technical areas: TA1 (CVD Agent), TA2 (Supervisory Agent), and TA3 (Scalable Implementation). Proposers are invited to submit solution summaries and proposals for one or more of these technical areas. The program seeks to improve cardiovascular disease management by enabling the development of autonomous and semi-autonomous clinical care systems. Some key features of the program include: * Development of a patient-facing, multimodal agentic system for clinical care * Creation of a disease-agnostic supervisory agent for real-time monitoring and control of clinical agents * Integration of clinical agents with EHR data and clinical workflows * Performance of large scalability studies to evaluate the safety and effectiveness of the clinical agents * Collaboration with healthcare organizations to implement and evaluate the clinical agents The program is open to eligible proposers, including small businesses, academia, and research institutions. Proposers are encouraged to form teams and collaborate with other organizations to submit proposals.

Attached files

Contact

[email protected] (note: this email address is explicitly marked as not for use)

Key dates

Opened
1/13/2026
Pre-bid meeting
1/23/2026
Closes
4/1/2026
Duration
15 months (for Phase 2)

Last updated

Details

Type
Request for Proposal
Industry
Healthcare and Medical Services
NAICS
541714
Solicitation №
ARPA-H-SOL-26-142

Budget estimate

$1,000,000 – $10,000,000

The budget for this opportunity is likely to be in the range of $1 million to $10 million, depending on the scope and complexity of the proposed project. The program is funded by ARPA-H, which provides funding for research and development of new technologies for healthcare applications. The funding amount will likely be determined based on the proposal's technical merit, relevance to the program's goals, and potential impact on cardiovascular disease management. Factors that may influence the likely payment range include the size and complexity of the proposed project, the experience and qualifications of the proposing team, and the potential for commercialization and scalability of the proposed technology.

AI estimate from the solicitation

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