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U.S. Department Of Energy·Ohio

TECHNOLOGY LICENSING OPPORTUNITY: SmartBind pH Switch

Closes 12/5/2025$200k – $5MRequest for Expression of Interest
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Description

The Los Alamos National Laboratory is offering a technology licensing opportunity for a pH-switchable version of Protein G, which gently captures and releases antibodies using mild pH changes. This innovation has several key advantages, including gentle elution conditions, improved antibody stability and yield, a switchable binding mechanism, and cost-effectiveness. The technology has various market applications, including biopharmaceuticals, life sciences research, bioprocessing and manufacturing tools, and veterinary and agricultural biotech. • The technology is at a development status of TRL 4. • The technology has a US provisional/patent number of 10,954,275. • The technology is available for licensing through exclusive and non-exclusive agreements. • The laboratory offers a range of cutting-edge technologies and capabilities to provide companies with a competitive edge in the market.

Attached files

Contact

Marc Witkowski

[email protected]

Key dates

Opened
11/13/2025
Closes
12/5/2025

Last updated

Details

Type
Request for Expression of Interest
Industry
Healthcare and Medical Services
NAICS
325413
Solicitation №
S-133461

Budget estimate

$200,000 – $5,000,000

The budget for this opportunity is difficult to estimate, as the document does not provide specific information on the licensing fees or royalties. However, considering the potential market applications and the competitive edge this technology could provide, it is possible that the budget could range from a few hundred thousand dollars to several million dollars, depending on the terms of the licensing agreement and the company's ability to commercialize the technology. Factors that may influence the likely payment range include the company's size, industry, and market position, as well as the level of competition and the demand for the technology.

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