Notice of Intent to Publish a Funding Opportunity Announcement for ClinGen Genomic Curation Expert Panels

The National Institutes of Health (NIH) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the establishment and continuation of Genomic Curation Expert Panels. These panels will manually curate, review, and define the clinical relevance of genes and variants as part of the NIH-established and funded Clinical Genome Resource (ClinGen). The goal is to address the need for better knowledge about the links between genes, variants, and disease. The Expert Panels will utilize the NHGRI ClinGen and the NCBI ClinVar procedures, interfaces, tools, and informatics infrastructure. • The NOFO will facilitate the development of Expert Panels to select genes and variants associated with diseases or conditions of high priority for participating NIH Institutes and Centers (ICs). • The Expert Panels will systematically determine the clinical significance of these genes and variants for diagnosis and treatment of diseases or conditions. • The panels will contribute to an authoritative, centralized, and public resource through aggregation, evaluation, and sharing of expert-curated data about genetic conditions and the variants that cause them.