Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)

The National Institutes of Health (NIH) invites applications to submit samples from pediatric cohorts for whole genome sequencing at a Kids First Program supported genomic data generating centers. The goal of this funding opportunity is to elucidate the genetic contribution to childhood cancers, investigate the genetic etiology of congenital anomalies, and study the molecular basis of the associations between congenital anomalies and increased cancer risk. The program will accept applications that propose whole genome, exome, and transcriptome sequencing, as well as clinical-grade sequencing, long-read sequencing, proteomics, and epigenomic assays of tumor or affected tissue, when justified. Key aspects of this opportunity include: * The application of genomic sequencing technologies to pediatric cohorts * The investigation of the genetic basis of childhood cancers and congenital anomalies * The study of the molecular basis of the associations between congenital anomalies and increased cancer risk * The expansion of the range of pediatric disorders included within the Kids First Data Resource * The sharing of data and associated clinical and phenotypic data with the research community.