NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed)

This opportunity is for investigator-initiated, high-risk multi-center observational studies involving more than one clinical center, focusing on diseases relevant to the mission of NIDDK. Proposed studies should be hypothesis-driven and completed prior to submission. Consultation with NIDDK Scientific/Research staff is strongly encouraged prior to the submission of either a U34 or U01 application. • The study should involve more than one clinical center. • The study should focus on a disease relevant to the mission of NIDDK. • Planning activities must be completed prior to submission. • Consultation with NIDDK Scientific/Research staff is strongly encouraged.