Description
The National Institutes of Health (NIH) is seeking a contractor to evaluate a lead NNMT inhibitor in humanized mouse models of chronic kidney disease. The contractor will provide preclinical contract research services, including animal production, efficacy studies, and laboratory analyses. The studies will be conducted using GemPharmatech's existing humanized NNMT mouse line, which was developed under a previous NIH-funded project. The contractor will recover the existing colony from cryopreserved sperm, produce approximately 50 male homozygous humanized NNMT mice, and conduct two efficacy studies using commercially available chronic kidney disease models. The contractor will also provide final study reports and progress updates.
• The contractor must provide commercially available preclinical contract research services, including all personnel, facilities, equipment, materials, and technical expertise necessary to perform the services described in the Statement of Work.
• The contractor must recover the existing humanized NNMT mouse line from cryopreserved sperm and produce approximately 50 male homozygous humanized NNMT mice.
• The contractor must conduct two efficacy studies using commercially available chronic kidney disease models.
• The contractor must provide final study reports and progress updates.
• The contractor must comply with all applicable laws, regulations, and NIH policies.