One Comprehensive Universal Radiotherapy for Everyone (1-CURE)

The Advanced Research Projects Agency for Health (ARPA-H) is seeking proposals for the One Comprehensive Universal Radiotherapy for Everyone (1-CURE) program. The goal of the program is to develop a revolutionary radiotherapy approach that is effective against all cancers with a single, rapid, and low-cost treatment. The program will focus on the integration of advanced ultra-high dose rate FLASH-RT with multifunctional immunogenic smart radiotherapy biomaterials (SRBs). Key aspects of the program include: • Developing multifunctional immunogenic nanoparticle SRBs that can guide FLASH-RT and boost abscopal responses through the release of immunoadjuvants. • Creating an Abscopal Treatment Planning System (ATPS) that integrates FLASH-RT and immunogenic SRBs to plan 1-CURE treatment for effective abscopal responses. • Ensuring the approach is widely accessible, with a dramatic reduction in treatment time and costs. • Addressing potential limitations of current RT biomaterials and treatment planning systems. • Leveraging enabling technologies such as FLASH-RT, smart nanoparticle technology, and artificial intelligence (AI).