A--Mouse Models for Down Syndrome

The National Institutes of Health is seeking a contractor to produce, maintain, and distribute aneuploid mice with a primary emphasis on models of human trisomy for chromosome 21. The contractor will be required to maintain a minimum of 30 breeding pairs of Ts65Dn mice and distribute them to researchers in the Down syndrome research community. The contractor will also be required to maintain and distribute additional models, including Dup(16)Yey, TcMAC21, and Ts66Yah. The contract will be for a period of one year, with options to extend for up to four additional years. The contractor will be required to submit technical progress reports, financial conflict of interest reports, and invention reports. Some key points to consider are: • The contractor must have experience in breeding and maintaining mice with genetic modifications. • The contractor must have a system in place for tracking and distributing mice to researchers. • The contractor must have a plan in place for managing and coordinating consultants and subcontractors. • The contractor must have a plan in place for sharing model organisms and research resources with the broader scientific community.