NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required)

This opportunity is for investigator-initiated, high-risk multi-center clinical trials involving more than one clinical center. The proposed trials should be hypothesis-driven, have the potential to change clinical practice and/or public health, and focus on a disease relevant to the mission of NIDDK. Key aspects of this opportunity include: • The requirement for a hypothesis-driven clinical trial with the potential to change clinical practice and/or public health • The focus on diseases relevant to the mission of NIDDK • The need for consultation with NIDDK Scientific/Research staff prior to submission • The availability of a cooperative agreement (U01) for clinical trials • The eligibility of various types of organizations, including non-profits, institutions of higher education, and small businesses