Description
The National Cancer Institute (NCI) is seeking to procure a software license for whole-genome sequencing. The software should be able to provide variant calling at high speed, with a 20-50 fold increase in processing speed, and maintain mathematical consistency. The software will be used to analyze a large number of tumor and normal tissue samples, and the NCI anticipates needing the software for the next five years. The contract will be a firm fixed-price purchase order, and the contractor shall provide software necessary to provide variant calling at high speed.
Some key features of the required software include:
* 20-50 fold increase in processing speed for key tools such as BWA-mem, STAR, minimap2, Picard, and GATK
* Exceptional accuracy and reproducibility for next-generation sequencing data variant calling
* Ability to process a 30x WGS sample data in under 30 minutes for less than $2 compute cost
* Support joint calling of large-number of WGS directly from VCFs without intermediate merging
* Support multiple complex use cases including short and long reads, germline and somatic variant calling, structural variants, copy number variants