In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed)

The National Institutes of Health (NIH) is seeking applications to phenotype and/or perform research on embryonic lethal knockout (KO) mouse strains generated through the International Mouse Phenotyping Consortium (IMPC). The goal is to create a comprehensive catalogue of mammalian gene function, providing the foundation for functional analyses of human genetic variation. • The mission of IMPC is to generate a null mutant and undertake broad-based phenotyping for every gene in the mouse genome. • About 30% of these strains are expected to be either embryonic or perinatal lethal, or subviable. • A large portion of homozygous lethal mutations are expected to have viable heterozygous phenotypes. • The scientific community has the unique opportunity to leverage these mouse strains while they are being created and bred as part of the IMPC adult mouse phenotyping effort to perform additional in-depth phenotyping and research. • Eligible applicants include various institutions, organizations, and governments. • The award ceiling is $499,999.