Bioinformatics Analysis of Livestock Genomics

The FDA's Center for Veterinary Medicine (CVM) requires external support to perform bioinformatics analysis of livestock genomics. The primary objective is to validate genomic variants in CRISPR/Cas9 gene-edited swine samples and generate breed-specific variant call files for cattle, chicken, and swine. The contractor will provide specialized bioinformatics services, including visual validation of genomic variants and generation of CRISPRme-ready input files. The contract will be a Firm Fixed Price contract with a period of performance of one year, from July 15, 2026, to July 14, 2027. Some key tasks include: • Conducting a post-award kickoff meeting to review project goals and establish communication protocols • Developing and documenting a standardized validation protocol for visual validation of genomic variants • Performing comprehensive quality control analysis of received sequencing data files • Generating breed-specific VCFs and CRISPRme input files for cattle, chicken, and swine • Delivering a final comprehensive analysis report detailing methodologies, findings, and interpretations The contractor must have prior experience working with CRISPR/Cas9 edited pig genomes and demonstrate a clear understanding of the statement of work requirements.