Mitochondrial-associated Mechanisms of Neuropathological and Immunodeficient Aging in the Context of HIV and SUD (R21 Clinical Trials Not Allowed)

The National Institutes of Health (NIH) is seeking research proposals to investigate the protective and pathogenic mechanisms at the nexus of mitochondria function and aging in the context of HIV infection and exposure to addictive substances. The goal of this research is to develop targeted therapies and improve outcomes in people aging with HIV, substance use, and addiction. Some key points to consider include: • The research should focus on mitochondrial-associated mechanisms of neuropathological and immunodeficient aging. • The context of HIV and SUD (Substance Use Disorder) is crucial for this research. • The NIH anticipates that this foundational knowledge could be leveraged to develop targeted therapies. • The research should aim to improve outcomes in people aging with HIV, substance use, and addiction.