Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency (SPECTRA)

The ARPA‑H “Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency” (SPECTRA) ISO seeks innovative, interdisciplinary solutions to map autism‑related developmental trajectories, integrate massive multimodal data, and create real‑world assessment and intervention technologies that improve diagnosis, personalized care, and quality of life across the lifespan. • Four Technical Areas (TA1‑TA4) covering multi‑factor trajectory analysis, population‑scale data integration, precision intervention testing, and wearable/communication technologies. • Solution Summaries (pre‑proposal) are mandatory; deadlines: TA4 Oct 18 2026, TA1/2 Dec 2 2026, TA3 Jan 18 2027. Full proposals to follow. • Funding via Other Transaction (OT) agreements; ARPA‑H expects commercial, academic, or non‑profit performers (no federal entities). • Emphasis on AI/ML, genomics, biosensing, wearables, and real‑world data capture; must address nonlinear interactions among genetics, environment, iatrogenic factors, etc. • Required SAM registration, UEI, and compliance with ARPA‑H IP, security, and publication policies. • No fixed budget disclosed; typical ARPA‑H OT awards range from several million to tens of millions of dollars. • Outcomes: earlier autism identification, trajectory‑guided precision therapies, everyday communication tools, and improved caregiver quality of life.