Kidney Precision Medicine Project Tissue Interrogation Sites (U01 Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) requests applications for Kidney Precision Medicine Project (KPMP) Tissue Interrogation Sites (TIS) to analyze human kidney tissue. The TIS will collaborate with the Recruitment Sites (RS), Kidney Tissue Atlas Coordinating Center (KTACC), and Central Hub (CH) to obtain and evaluate kidney biopsies from participants with acute kidney injury (AKI) or chronic kidney disease (CKD), create a Kidney Tissue Atlas, define disease subgroups, and identify critical cells, interstitial components, pathways, and targets for novel therapies. The key aspects of this opportunity include: • The TIS will use highly integrated multi-modal analytic pipelines to interrogate human kidney biopsy tissue. • The project aims to discover and define new disease pathways and subgroups that enable precision clinical trials. • All KPMP personnel will actively participate in scientific discovery and promote open science. • The funding opportunity announcement includes a Data Management and Sharing Plan, which is required for any NIH-funded or conducted research that will generate scientific data.