Description
The U.S. Food and Drug Administration (FDA) is seeking a CICERO/THUNDER Imager Spinning Disk or equal upgrade to an existing Leica DMi8 microscope. The upgrade should include advanced camera capabilities and specialized objectives for high-resolution imaging. The contract includes a one-year warranty and options for two additional years of preventive maintenance-repair service. The contractor will be responsible for providing all necessary components, installing the equipment, and providing on-site operator training.
Key features of the upgrade include:
* Dual Imaging Modes, allowing for seamless transition between traditional camera-based widefield and physical confocal spinning disk modes
* True Optical Sectioning Hardware, using a CrestOptics CICERO spinning disk unit to physically block out-of-focus light
* Quantitative Fluorescence Measurements with Reduced Background Bias, providing more reliable intensity measurements
* Significantly Improved Axial (Z) Resolution, enabling cleaner 3D reconstructions of thick specimens
* High-Powered Diode Lasers, providing higher irradiance for improved signal in deep or densely labeled samples
* Synergistic Blur Removal, allowing for mathematical removal of residual pinhole crosstalk and haze
* Reduced Phototoxicity and Photobleaching, minimizing phototoxicity and photobleaching for live-cell imaging
* High-Speed Acquisition, enabling frame rates of up to several hundred frames per second for large samples and live-cell imaging.