Limited Competition: Competing Revisions to Support Clinical Trials in Somatic Cell Genome Editing (U19 Clinical Trial Required)

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit competitive revision applications from awardees with active U19 awards funded under RFA-RM-22-015 as part of the NIH Somatic Cell Genome Editing program. The goal is to expand the scope of the original award to allow first-in-human genome editing clinical trials using the therapeutic clinical candidates developed through the U19 award. Key aspects of the job include: • Developing and conducting clinical trials for genome editing • Expanding the scope of the original U19 award to include clinical trials • Utilizing therapeutic clinical candidates developed through the U19 award • Collaborating with the NIH Somatic Cell Genome Editing program The work and scope of the project involve conducting clinical trials, which will require significant resources and expertise. Applicants should have experience in genome editing, clinical trials, and working with the NIH.