National Amyotrophic Lateral Sclerosis (ALS) Biorepository’s Augmentation of ALS Samples for Researchers through an Established External Repository

The Centers for Disease Control and Prevention (CDC) is seeking a contractor to provide high-quality ALS samples for researchers. The contractor must have a nationally recognized tissue core repository with extensive experience in facilitating and providing tissue samples and data to academic and industry laboratories worldwide. The repository should include frozen and fixed CNS tissues, liver, and several muscles from ALS/MND and non-neurologic control autopsies. The contractor should also have standard operating procedures for tissue dissection, processing, QC analysis, clinical data elements, and neuropathological characterization. Some key requirements include: • A large collection of ALS samples from the Guam cluster • A dissection method that produces the maximum number of individual, optimally sized tissue samples from each ALS-relevant region • Standard Operating Procedures for tissue dissection, processing, QC analysis, clinical data elements, and neuropathological characterization • A repository compromised of frozen and fixed CNS tissues, liver, and several muscles from ALS/MND and non-neurologic control autopsies