NOI - Dynamic Genome: CHIP

The National Institutes of Health (NIH) is seeking a specialist in CHIP research to identify clonal hematopoiesis of indeterminate potential (CHIP) in longitudinal whole genome sequencing datasets. The contractor will perform computational data analysis to call somatic mutations and clonal hematopoiesis of indeterminate potential (CHIP) in whole genome sequence data from two timepoints. The work requires consistency with prior analyses to support accurate longitudinal comparison and ongoing research into cardiovascular disease and related conditions. Key aspects of the job include: • Accessing FHS data and WGS data from TOPMed Data Exchange • Performing computational data analysis to call somatic mutations and clonal hematopoiesis of indeterminate potential (CHIP) • Collaborating with the NHLBI intramural team on subsequent analyses and publications • Delivering results by September 30, 2026