HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Clinical Trial Center and Clinical Centers (U01 Clinical Trial Optional)

The National Institutes of Health (NIH) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for a new Clinical Trial Center (CTC) and up to seven Clinical Centers (CCs) for the HeartShare 2.0 program. The CTC will coordinate precision clinical trial activities focused on heart failure with preserved ejection fraction (HFpEF), while the CCs will recruit and retain heart failure patients and controls. Key aspects of the job include: • Master protocol development • Project management • Recruitment oversight • Performance milestones • Scientific conduct of trials • Deep phenotyping protocol and longitudinal follow-up of HFpEF patients • Obtaining tissue biopsies • Interpreting and translating results • Supporting future clinical trials.