Omics Phenotypes Related to Down Syndrome for the INCLUDE Project (X01 Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) invites applications to use the NIH INCLUDE Project to access resources to generate a large volume of integrated genomic and multi-omics data to facilitate discovery of the molecular mechanisms of health conditions related to Down syndrome. The program will accept applications that propose whole genome sequencing, including both short-read and long-read, exome, epigenome, and transcriptome sequencing, as well as proteomic, metabolomic, and single-cell RNA sequencing and ATAC sequencing, when justified. • The opportunity is open to various types of applicants, including state governments, county governments, city or township governments, and non-profit organizations. • The program aims to generate a large volume of integrated genomic and multi-omics data to facilitate discovery of the molecular mechanisms of health conditions related to Down syndrome. • Applicants are encouraged to propose cohorts of underrepresented racial and ethnic groups or to increase racial and ethnic representation of existing collections. • The omics data and related phenotypic data will be deposited in a public INCLUDE Project controlled-access database.