Intent to Sole Source - Untargeted Metabolomics Analysis

The National Institutes of Health Clinical Center (NIH‑CC) is issuing a Notice of Intent to sole‑source a contract to Metabolon, Inc. for untargeted metabolomics analysis of human fecal samples. The work supports a collaborative study with the NIDDK and NHLBI to compare microbiome‑derived metabolites and dietary xenobiotics in diets of varying processing levels. The vendor must detect and quantify a broad panel of small‑molecule metabolites, enable simultaneous cytokine/chemokine/metabolite analysis in small volumes, interface with Thermo Fisher Luminex platforms, and provide validated untargeted coverage for fecal matrices. Interested responsible sources may submit a capability statement by the stated deadline; the Government will decide whether to proceed without competition. • Sole‑source solicitation (NOI) – no competitive RFP. • Service: high‑throughput untargeted metabolomics on human fecal samples. • Required capabilities: broad small‑molecule detection, low‑volume multiplexed analysis, Luminex integration, validated fecal protocols. • Submission: capability statement via email (subject line NOI‑CC‑OLAO‑26‑008751) by 12:00 PM EST 08/31/2026. • Agency: NIH Clinical Center, TBHP Branch. • Potential contract value not disclosed; likely a multi‑sample analytical services agreement.